Neutralization Of Animal Viruses (Current Topics in Microbiology & Immunology)

This is the first comprehensive review of the neutralization of animal viruses for several decades, intended to provide a clear exposition of current knowledge and to outline avenues for future research. The approach is mechanistic; the aim is to understand the process of neutralization and, ultimately, to determine how neutralizing and/or protective antibody can be stimulated in vivo. Chapters discuss the ways in which neutralizing IgG, A and M affect the interactions of virus with its host cell, quantitative aspects of neutralization, neutralization by fragments of antibody, neutralization in vivo, and the evolutionary significance of the possession of neutralization sites. In addition, individual chapters are devoted to the neutralization of poliovirus, influenza virus and HIV.