A Microfluidic Platform for Human Epidermal Keratinocyte Cytotoxicity Assays

A Microfluidic Platform for Human Epidermal Keratinocyte Cytotoxicity Assays

136 pages· 2009· ISBN 9781109160864
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My research involves developing a microfluidic platform for high throughput cytotoxicity screening. Specifically, this 'lab on a chip' device creates distinct dilutions of a potential toxicant in a buffer solution and delivers these solutions to human skin cells in microchannel cultures. Results have indicated that a dosage dependency relationship exists between toxicant concentration and cell proliferation, recovery behavior, cell viability, and secreted irritation markers.

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