Metabolism and Disease

"The Symposium aimed to integrate a very broad field of investigative effort, bringing together advances in our understanding of energy intake, consumption, and storage (diet, exercise, and fat), oxygen regulation and hypoxia, circadian rhythms, and life span/aging. The Symposium explored metabolism at molecular (gene expression, posttranslational modifications, protein turnover, cofactors and integrators, hormones, and signals), organellar (mitochondria), cellular, organ system (cardiovascular, bone), and organismal (timing and life span) scales. Diseases impacted by metabolic imbalance or dysregulation that were covered in detail included diabetes, obesity, metabolic syndrome, and cancer. New and emerging technologies were presented for simultaneous monitoring of hundreds of metabolites that allow for sophisticated sampling of the metabolic state of cells. Because the Symposium covered such a broad field, by necessity much excellent work could not be included, and instead, the Proceedings should be viewed as a necessarily eclectic collection of some of the most interesting and stimulating work that came to the organizers' attention during the 18 months before the meeting"--P. xv.