Hidden Markov Models Predict Epigenetic Chromatin Domains

Hidden Markov Models Predict Epigenetic Chromatin Domains

by Jessica Lynn Larson

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Epigenetics is an important layer of transcriptional control necessary for cell-type specific gene regulation. We developed computational methods to analyze the combinatorial effect and large-scale organizations of genome-wide distributions of epigenetic marks. Throughout this dissertation, we show that regions containing multiple genes with similar epigenetic patterns are found throughout the genome, suggesting the presence of several chromatin domains.

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