Importance of the Pre-NH2-Terminal Domain of HSV-1 DNA Polymerase for Viral Replication

Importance of the Pre-NH2-Terminal Domain of HSV-1 DNA Polymerase for Viral Replication

by Shariya Terrell

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The catalytic subunit of the herpes simplex virus 1 DNA polymerase (HSV-1 Pol) has been extensively studied; however, its full complement of functional domains has yet to be characterized. The previously uncharacterized pre-NH2-terminal domain (residues 1-140) within HSV-1 Pol is unique to the herpesvirus Pol family. We sought to investigate the importance of this domain for viral replication in cell culture and an animal model of infection.

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