Targeting MRNA Stability as a Potential Therapeutic for LPS-induced Inflammatory Bone Loss

Targeting MRNA Stability as a Potential Therapeutic for LPS-induced Inflammatory Bone Loss

160 pages· 2007· ISBN 9781109028607
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These data indicate that targeting mRNA stability via the over expression of TTP inhibits the production of pro-inflammatory cytokines and protects animals from LPS-induced bone loss. Collectively, these data support the role of mRNA stability as a therapeutic target for management of inflammation-driven bone loss as found in periodontitis.

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