Chemistry and Biology of Pteridines and Folates 1997

Chemistry and Biology of Pteridines and Folates 1997

Proceedings of the Eleventh International Symposium on Pteridines and Folates, Berchtesgaden, Germany, June 15-20, 1997

by Wolfgang Pfleiderer

894 pages

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About
These papers are the proceedings of the International Symposium on the Chemistry and Biology of Pteridines and Folates. The book brings together contributions from some 250 scientists from chemistry, biochemistry, biology, pharmacology, and medicine to present and discuss recent advances in this expanding field. Pteridines fulfil many roles in nature, ranging from pigments to essential co-factors for numerous redox and carbon transfer reactions. This large diversity of function is unified by the unique chemistry of the pteridine heterocycle. Emphasis in the book is given to: the progress of antifolates in cancer therapy, with emerging new compounds of broad range effectiveness and with gene therapeutic approaches; on the role of folates in nutrition and their pathological changes; and on new findings in pteridine and folate enzymes.

Discussion questions for Chemistry and Biology of Pteridines and Folates 1997

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  1. 1

    How does the unique chemical structure of the pteridine heterocycle allow it to serve such a remarkably diverse range of functions in nature, from pigmentation to acting as essential enzymatic co-factors?

  2. 2

    How does the unique chemical structure of the pteridine heterocycle allow it to serve such a vast and diverse array of functions in nature, from pigmentation to acting as an essential redox co-factor?

  3. 3

    Considering the heavy emphasis on antifolates in cancer therapy within these proceedings, how do you view the balance between targeting rapid cell division and minimizing systemic toxicity in modern pharmacology?

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