Vasopeptides:Chemistry, Pharmocology and Pathophysiology

The dynamic state of developments within the field of the vasoactive polypeptides is reflected in the continuous series of publications appearing on this topic. Thus, the proposal to convene another symposium only two years after the 1969 Fiesole Symposium (Plenum Press, 1970) was received enthusiastically and with high expectation. Enthusiasm was based, undoubtedly, in part on meeting together once again in the very pleasant surroundings of Florence with most gracious and enchanting hosts. The 25th International Congress on Physiological Sciences held in Munich the following week also provided the impetus for the organization of this satellite symposium on vasopeptides. However, the accelerated pace of research in the "kinin" field was the major motivating force for the symposium. It was felt necessary to inform each other of the many advances that were taking place in the varied aspects of this specialized but important field. The role of kinins in both physicologic and pathologic processes still remains to be elucidated definitively. Thus, these proceedings contain new and unpublished information on the chemistry, biochemistry, physicology, pharmacology, as well as pathophysiology of vasopeptides. Recent data on atructureactivity relationships of kinin analogues are complemented by a description of radioimmunoassay techniques for kinins, and studies on the site of synthesis of substrates for kinin-forming enzymes. Under intensive study, and securing an important place in the symposium, are the studies of the interaction of the kinin-forming system with components of the fibrinolysin, blood coagulation, and complement systems. The primary role of Hageman factor in the release of kinins receives additional support. Included in the proceedings are studies on tissue localization of kinin-forming enzymes, the metabolic fate of various vasopeptides and prostaglandins, and identification of a bradykinin-potentiating peptide. The pharmacologic actions of several vasopeptides also are highlighted. The pathophysiology of such conditions as toxemia of pregnancy, inflammation, cold injury, shock, malignancy, hypertension, myocardial infarction, and liver cirrhosis is reconsidered in terms of the role of vasopepetides. The more informal and intimate discussions with colleagues comprised a very delightful and informative part of the meeting.