EXPLORING THE USE OF HUMAN PLURIPOTENT STEM CELLS TO CREATE FUNCTIONAL PANCREATIC β CELLS

EXPLORING THE USE OF HUMAN PLURIPOTENT STEM CELLS TO CREATE FUNCTIONAL PANCREATIC β CELLS

by Sinisa Hrvatin

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Directed differentiation of human pluripotent stem cells (hPSCs) has the potential to produce human cell types that can be used for disease modeling and cell transplantation. Two key challenges in the differentiation from hPSCs to beta cells are the specification from pancreatic progenitors to insulin-expressing (INS+) cells and the maturation of INS+ cells into glucose responsive beta cells.

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