Modern Statistical/Machine Learning Techniques for Bio/Neuro-imaging Applications

Developments in modern bio-imaging techniques have allowed the routine collection of a vast amount of data from various techniques. The challenges lie in how to build accurate and efficient models to draw conclusions from the data and facilitate scientific discoveries. Fortunately, recent advances in statistics, machine learning, and deep learning provide valuable tools. This thesis describes some of our efforts to build scalable Bayesian models for four bio-imaging applications: (1) Stochastic Optical Reconstruction Microscopy (STORM) Imaging, (2) particle tracking, (3) voltage smoothing, (4) detect color-labeled neurons in c elegans and assign identity to the detections.