Dissecting Protein-protein Interactions that Regulate the Spindle Checkpoint in Budding Yeast

Dissecting Protein-protein Interactions that Regulate the Spindle Checkpoint in Budding Yeast

by Tsz Cham Derek Lau

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Errors in segregation of genetic materials are detrimental to all organisms. The budding yeast ensures accurate chromosome segregation by employing a system called the spindle checkpoint. The spindle checkpoint, which consists of proteins such as Mad1, Mad2, Mad3, Bub1, and Bub3, monitors the attachment of microtubules to the chromosomes and prevents cell cycle progression until all chromosomes are properly attached.

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