Handbook of Porphyrin Science (Volumes 26 – 30)

This is the sixth set of Handbook of Porphyrin Science. This 5-volume set provides a comprehensive review of the most up-to-date research on porphyrin, heme and chlorophyll biochemistry, as well as applications to biomedicine and bio-inspired energy. In-depth coverage of topics along with perspectives on outstanding questions and future research directions by the authors make these volumes an essential resource for both beginning and advanced investigators in the field. It is also suitable for non-experts in porphyrin, who wish to have an overview of the fundamental discoveries and breakthroughs in the porphyrin arena related to medicine and bio-inspired energy. Bringing together the biochemistry of porphyrin-binding proteins and their clinical relevance and applications to medicine and renewable energy, this set provides readers with an integrated coverage of porphyrin biochemistry. At the same time, it challenges readers with new questions and perspectives of research regarding the role of porphyrin biochemistry in the future of medicine and renewable energy. Contents: Volume 26: Heme Biochemistry:Toward Heme: 5-Aminolevulinate Synthase and Initiation of Porphyrin Synthesis (Erica J Fratz, Bosko M Stojanovski and Gloria C Ferreira)The Dance of Porphobilinogen Synthase in the Control of Tetrapyrrole Biosynthesis (Eileen K Jaffe and Sarah H Lawrence)The Ultimate Step of Heme Biosynthesis: Orchestration Between Iron Trafficking and Porphyrin Synthesis (Mallory E Gillam, Gregory A Hunter and Gloria C Ferreira)Heme-Delivering Proteins in Bacteria (Cécile Wandersman and Philippe Delepelaire)Porphyrin and Heme Trafficking in Metazoans (Iqbal Hamza and Harry A Dailey)Extracellular Heme Uptake and Metabolism in Bacterial Pathogenesis (Angela Wilks and Maura J O'Neill)Heme and Infectious Diseases (Allison J Farrand and Eric P Skaar)Biliverdin Reductase: Its Multiple Functions in Cell Signaling and Role in Cytoprotection (Mahin D Maines and Peter E M Gibbs)Reactivity and Structure in the CDE Protein Superfamily: From O2 Generation to Peroxidase Chemistry and Beyond (Jennifer L DuBois, Christopher J Carrell and Carrie M Wilmot)Volume 27: Erythropoiesis, Heme and Applications to Biomedicine:Differential Regulation of 5-Aminolevulinate Synthase Isozymes in Vertebrates (Kazumichi Furuyama and Masayuki Yamamoto)Erythropoiesis, Hemoglobin Synthesis, and Erythroid Mitochondrial Iron Homeostasis (Prem Ponka, Mark J Koury and Alex D Sheftel)Zebrafish as a Genetic Model of Hematopoiesis and Human Red Blood Cell Diseases (Dhvanit I Shah and Barry H Paw)Hemoglobin and Hemoglobin-based Oxygen Carriers: A Biochemical, Pharmacological, and Toxicological Perspective (Yiping Jia, Claudia P Pereira and Paul W Buehler)Unique Features of Heme Biosynthesis in the Malaria Parasite (Govindarajan Padmanaban, V Arun Nagaraj and Pundi N Rangarajan)Iron(III) Protoporphyrin IX and Hemozoin: Key Targets in the Chemotherapy of Malaria (Katherine A de Villiers and Timothy J Egan)Cyclic Tetrapyrroles in Photodynamic Therapy: The Chemistry of Porphyrins and Related Compounds in Medicine (Tyler G St Denis, Ying-Ying Huang and Michael R Hamblin)Porphyrin Conjugates for Cancer Therapy (Francesca Giuntini, Ross Boyle, Martha Sibrian-Vazquez and M Graça H Vicente)Volume 28: Chlorophyll, Photosynthesis and Bio-inspired Energy:Structural Analysis of Photosynthetic Proteins (Christopher Kupitz, Raimund Fromme, Ingo Grotjohann and Petra Fromme)Magnesium Chelatase: The Molecular Motor of Chlorophyll Biosynthesis (Mats Hansson, Joakim Lundqvist, Nick Sirijovski and Salam Al-Karadaghi)The Magnesium Branch of Tetrapyrrole Biosynthesis: From Magnesium Protoporphyrin IX to Chlorophyll a/b (Annabel Salinas and Bernhard Grimm)Chlorophyll Breakdown: Chemistry, Biochemistry, and Biology (Bernhard Kräutler and Stefan Hörtensteiner)Phycobiliproteins — Biosynthesis, Assembly and Applications (Kristina E Overkamp and Nicole Frankenberg-Dinkel)Binary Ionic Porphyrin Nanomaterials for Energy from Sunlight (John A Shelnutt, Yongming Tian, Kathleen E Martin and Craig J Medforth)Porphyrin-Sensitized Solar Cells (Eric Wei-Guang Diau and Lu-Lin Li)Volume 29: Porphyrias and Sideroblastic Anemias:The Structural Basis of Porphyrias — Defects of Heme Biosynthetic Enzymes (Anna-Lena Kaufholz, Gunhild Layer, Dirk Heinz, Martina Jahn and Dieter Jahn)Sideroblastic Anemias: Molecular Basis, Pathophysiology, and Clinical Aspects (Sylvia S Bottomley and Mark D Fleming)Heme Biosynthesis and Pathophysiology of Porphyrias (Zoubida Karim, Laurent Gouya, Jean-Charles Deybach and Hervé Puy)Clinical and Molecular Epidemiology of the Porphyrias (Michael N Badminton, George H Elder and Sharon D Whatley)Congenital Erythropoietic Porphyria (Jordi To-Figueras, Oscar Millet and Carmen Herrero)Porphyria Cutanea Tarda (Ashwani K Singal and John D Phillips)Variegate Porphyria (Peter Meissner, Anne Corrigall and Richard Hift)Erythropoietic Protoporphyria and X-Linked Dominant Protoporphyria (Xiaoye Schneider-Yin and Elisabeth I Minder)Liver Transplantation in Acute Hepatic Porphyria and Erythropoietic Protoporphyria (Staffan Wahlin and Pauline Harper)Clinical and Laboratory Diagnosis of the Porphyrias (Karl E Anderson)Liver Gene Therapy Approaches for Acute Intermittent Porphyria: Metabolic Correction and Immunological Hurdles (Antonio Fontanellas and Ignacio Melero)Cellular and Gene Therapy for Erythropoietic Porphyrias (Emmanuel Richard, Cécile Ged, Aurélie Bedel, François Moreau-Gaudry and Hubert de Verneuil)Volume 30: Heme Proteins — Part II:Porphyrin Modifications in the Autocatalytic Maturation of Hemoproteins (Paul R Ortiz de Montellano)Thiol/Disulfide Redox Switches as a Regulatory Mechanism in Heme-binding Proteins (Stephen W Ragsdale, Nirupama Gupta, Ireena Bagai, Andrea Morris Spencer and Eric Carter)Non-Canonical Heme-Binding Proteins (Luciana Hannibal and Dennis J Stuehr)Heme-Regulated Inhibitor (HRI) eIF2α Kinase and the Heme-Regulated Turnover of Cytochromes P450 and Other Hepatic Proteins (Maria Almira Correia, Yi Liu, YongQiang Wang, Mingxiang Liao, Juan Engel and Shenheng Guan)Bacterioferritin: Structure Function and Protein–Protein Interactions (Mario Rivera)Nuclear Magnetic Resonance as a Tool to Characterize the Interactome of Heme Proteins (Daniela Lalli and Paola Turano)Mimicking Heme Enzymes in the Solid State (Randy W Larsen)Biophysical Perspectives on the Acquisition, Transport, and Trafficking of Heme in Bacteria (Kenton R Rodgers and Gudrun S Lukat-Rodgers)Protection against Heme Toxicity: Hemopexin Rules, OK? (Ann Smith) Readership: Graduate students, academics, researchers, and healthy and industry professionals in the fields of heme and chlorophylls and their application to biomedicine and bio-inspired energy.Keywords:Acute Hepatic Porphyria;Acute Intermittent Porphyria;5-Aminolevulinate Synthase;Antimalarial Drugs;Bacterioferritin;Biliverdin Reductase;Biomedicine;Boron Clusters;Cancer Therapy;Chlorophyll;Congenital Erythropoietic Porphyria;Cytochrome P450;Embryogenesis;Epidemiology;Erythropoiesis;Erythropoietic Protoporphyria;Gene Therapy;Genetic Modifiers;Heme;Heme-Regulated Inhibitor (HRI) eIF2a Kinase;Heme Homeostasis;Hemoglobin;Hemoglobin-Based Oxygen Carriers;Hemopexin;Hemoproteins;Hereditary Coproporphyria;Insulin;Interactome;Iron Homeostasis;Laboratory Diagnosis;Liver Transplantation;Magnesium Chelatase;Malarial Parasite;Porphyrias;Porphyria Cutanea Tarda;Porphyrin Modifications;Porphyrin Nanostructures;Photosynthesis;Phycobiliproteins;Renewable Energy;Sideroblastic Anemias;Solar Cells;Sustainable Energy;Thiol/Disulfide Redox Switches;Variegate Porphyria;ZebrafishKey Features: Consists of thousands of pages of articles written by internationally recognized experts in the field along with thousands of relevant literature citations The biological and medical relevance of porphyrins is linked to their chemical, physical and structural features A vast array of information on porphyrin science consolidated into an up-to-date multi-volume series of clear and concise coverage, including hundreds of figures, tables and structural formulas Of interest to chemists, physicists, material scientists, polymer scientists, spectroscopists, electrochemists, electronics and photonics engineers, biochemists, biophysicists, medicinal chemists and clinicians The topics have been selected to give readers the broadest perspective of the amazing developments in the biochemistry of porphyrin-binding proteins, on how the malfunction of these proteins has disastrous consequences in life processes and how knowledge of their biochemical mechanisms can be applied to advances in biomedicine and new forms of energy